Introduction: This remedy is of service in cases of leucoderma and squamous syphilides, the indication being chafing about the genitals.This is a remedy that will be needed in cases that look like the old malaria patients with abuse of quinine. It will be of use when there is great weakness and lack of reaction and in cases where eruptions have been suppressed and a chronic condition has settled in. It should be tried in chronic, obstinate, and long standing asthma cases complicated with rheumatic and arthritic conditions, especially when Sulphur or Arsenicum or both have been tried with only partial effect.Synonym: Arsenious SulphideOrpiment, As2S3Source: yellow sulphuret of arsenic. This is a lemon-yellow powder, becoming darker when heated, and is without taste or odor.Preparation: TriturationsParticulars: Mind: Patient is very irritable, quarrelsome, very sensitive and touchy. Fear at night of dark, of evil and ghosts. Fear of cloud also. Suspicious of his friends and family. Weeping at night and occasionally weeps during sleep.Digestive symptom:Ravenous appetite with easy satiety, aversion to fat food, meat and stimulant. Very thirsty. Milk upsets the stomach. Desires warm things, constipation alternating with diarrhoea.Urine: Dribbling, painful, difficult and at times involuntary at night. Must hurry up or urine escapes.Sex: Stitches in glans penis and scrotum. Perspiration genitalia. Ulcers prepuce. Itching of vulva. Leucorrhoea excoriating, menses copious and too frequent.Extremities: Cold hands and feet, cramps, calf muscles and soles, pain in the limbs after midnight.Sleep: Deep, dreams amorous, anxious of death and of the dead. Wide awake 3 am and start to sleep after.Skin: Marked coldness of the skin of the body. Discoloration of skin. Blotches blue, liver spots and white spots. Eruptions itching moist modular urticaria. Purpura haemorrhagia.Constitution Dose and administration: 1 tab 3 to 4 times daily for adult. ½ tab for 3 to 4 times daily children.Side effects: No significant side effect has been observed in proper dosageContraindication: There is no known contraindication.Relationship:Arsenic sulph. rub. (influenza with intense catarrhal symptoms, great prostration and high temperature, purulent discharges, psoriasis, acne, and sciatica. Chilly even before a fire. Itching in various parts. Pellagra.)